Cirneco Oculo-Neurological Syndrome in Dogs

Breeds documented
1
Published sources
1

Overview

A rare syndrome reported in Cirneco dell'Etna dogs combines damage to the retina, the light-sensing tissue inside the eye, with episodes of abnormal movement. The first study described two affected littermates with declining vision, head tremors and unusual front-leg movements. Researchers identified a likely associated change in the AMPD2 gene, but emphasized that more cases are needed to confirm its role.

Signs to watch for

  • Episodes of head bobbing or tremors while remaining conscious
  • A front leg lifting or moving as though it is cramping
  • Worsening vision

In the two published cases, movement episodes began around 2 to 2.5 years; eye disease was confirmed around four years.

When to get help Arrange a vet visit for head tremors or worsening vision.

Diagnosis and tests

The published cases underwent specialist eye and neurological examinations, with brain MRI to investigate the abnormal movements. Examination of the back of the eye confirmed retinal degeneration. Researchers also tested for an AMPD2 variant, but its proposed link to the syndrome still needs confirmation in more dogs.

Breeds with documented risk

1 breed

By breed size
  • 1 Medium

Inheritance

  • Not yet known

    None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.

Sources

  1. ebi.ac.uk