Golden Retriever Progressive Retinal Atrophy 2 in Dogs

Category: Eye
Breeds documented: 2
Published sources: 7

Overview

GR-PRA2 is an inherited form of progressive retinal atrophy linked to a change in the TTC8 gene. It damages the retina, the light-sensitive layer at the back of each eye, and gradually reduces vision. Night vision is often affected before daytime sight, and blindness can develop as the disease progresses. Research in affected Golden Retrievers has also described problems outside the eyes, including kidney changes and loss of smell.

Signs to watch for

Difficulty finding the way in low light
Hesitating on stairs
Bumping into doorways in unfamiliar surroundings
Unusually bright reflections from the eyes

Signs of GR-PRA2 can appear around four years of age.

When to get help Arrange a vet visit if your dog's night vision or movement around obstacles changes.

Diagnosis and tests

Diagnosis combines an examination of the retina with testing for the TTC8 gene variant. A DNA test for GR-PRA2 can distinguish carriers from dogs with two copies of the variant. Genetic testing and eye examinations complement each other because Golden Retrievers can have other genetic forms of progressive retinal atrophy.

Breeds with documented risk

2 breeds

By breed size

2 Large

Labrador RetrieverLarge · Sporting Group
Golden RetrieverLarge · Sporting Group

Inheritance

Not yet known
None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.