Mucopolysaccharidosis Type VII in Dogs

Category: Bone & Joint
Breeds documented: 2
Published sources: 5

Overview

An inherited shortage of an enzyme called beta-glucuronidase prevents cells from breaking down certain complex sugars. These substances build up inside cells and can damage tissues throughout the body. Known as mucopolysaccharidosis type VII, the disorder can disrupt skeletal growth and make standing or walking difficult. Eye changes, enlarged organs and heart problems can also occur, with severity differing between affected dogs.

Signs to watch for

Growing much more slowly than expected.
Shortened, crooked or misshapen legs.
Difficulty standing or walking.
Cloudiness over the eyes.

Signs can begin in the first weeks of life, although timing and severity vary.

Emergency Go to an emergency vet now if your puppy has difficulty walking.

Diagnosis and tests

Examination and X-rays can reveal abnormal bone growth, while urine testing may suggest a storage disorder. Measuring enzyme activity and DNA testing can confirm the specific form. PennGen offers a DNA test for the known German Shepherd variant. A different change in the GUSB gene has been identified in Brazilian Terriers.

Breeds with documented risk

2 breeds

By breed size

1 Small
1 Large

German ShepherdLarge · Herding Group
Brazilian TerrierSmall · Foundation Stock Service

Inheritance

Not yet known
None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.