Neuronal Ceroid Lipofuscinosis 10 in Dogs

Category: Nervous System & Behavioral
Breeds documented: 1
Published sources: 5

Overview

The type 10 form of neuronal ceroid lipofuscinosis, or NCL10, is linked to a change in the CTSD gene. Abnormal material collects inside nerve cells, and the nervous system gradually deteriorates. Dogs can develop poorly controlled steps and weakness in their back legs. In reported American Bulldogs, the disease worsened over several years, with loss of the ability to walk occurring late.

Signs to watch for

Poorly controlled, exaggerated movements of the legs
Weakness in the back legs
Walking difficulties that gradually become more severe
Inability to walk in advanced disease

Reported signs begin in young adulthood and worsen gradually.

When to get help Arrange a veterinary visit soon if leg coordination or walking ability changes.

Diagnosis and tests

A vet evaluates the dog's movement problems and their progression. A DNA test for the known CTSD variant can identify this genetic form. Microscopic examination can reveal characteristic storage material in nerve cells. The genetic result helps distinguish NCL10 from other conditions with similar neurological signs.

Breeds with documented risk

1 breed

By breed size

1 Large

American BulldogLarge · Foundation Stock Service

Inheritance

Not yet known
None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.