Renal amyloidosis in Dogs

Category: Urinary & Reproductive
Breeds documented: 1
Published sources: 4

Overview

Abnormal protein material called amyloid can collect in kidney tissue and interfere with its work. When deposits affect the kidneys' filters, large amounts of protein may leak into urine. Over time, the damage can lead to kidney failure. Some cases are inherited, while others are linked with long-lasting inflammation or another illness. The disease may develop quietly and be difficult to recognize from outward signs alone.

Signs to watch for

Drinking and urinating more than usual
Reduced appetite or refusing food
Vomiting
Losing weight
Being unusually tired or less active

Most often recognized in middle-aged or older dogs, but inherited cases can appear earlier.

When to get help Book a vet visit promptly if thirst, urination, appetite or weight changes.

Diagnosis and tests

Blood and urine tests can reveal kidney damage and protein loss, which may raise suspicion of amyloidosis. Confirmation relies on examining a kidney tissue sample under a microscope. Special staining helps the laboratory identify amyloid deposits. The vet also investigates illnesses or persistent inflammation that could be contributing to the deposits.

Breeds with documented risk

1 breed

By breed size

1 Medium

Chinese Shar-peiMedium · Non-Sporting Group

Inheritance

Not yet known
None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.