X-Linked Progressive Retinal Atrophy 1 in Dogs

Category
Eye
Breeds documented
2
Published sources
7

Overview

A change in the RPGR gene causes this inherited form of progressive retinal atrophy, reported in Samoyeds and Siberian Huskies. The retina, the light-sensing tissue at the back of the eye, develops before degeneration begins. Its cells then gradually stop working, leading to vision loss. Progression can take several years, and affected dogs may become blind as the disease advances.

Signs to watch for

  • Hesitating in dark rooms or outside after sunset.
  • Bumping into objects in unfamiliar places.
  • Pupils that look unusually large.

Degeneration begins in young dogs after retinal development and progresses over several years.

When to get help Book a vet visit when you notice changes in your dog's vision.

Diagnosis and tests

A DNA test can detect the RPGR variant associated with XLPRA1. A vet examines the retina for degeneration and may refer the dog to an eye specialist. An electroretinogram measures the response to light and may detect problems before obvious retinal changes appear.

Breeds with documented risk

2 breeds

By breed size
  • 2 Medium

Inheritance

  • Not yet known

    None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.

Sources

  1. pubmed.ncbi.nlm.nih.gov
  2. med.upenn.edu
  3. vet.cornell.edu
  4. vet.tufts.edu
  5. ofa.org
  6. merckvetmanual.com
  7. Samoyed: omia.org