Glycogen Storage Disease Type IIIA in Dogs

Category: Liver
Inheritance: Autosomal recessive
Breeds documented: 1
Published sources: 5

Overview

When the enzyme that breaks down stored glycogen does not work, this carbohydrate accumulates in the liver and muscles. The buildup can damage muscle fibers and cause progressive scarring of the liver. Some affected dogs have episodes of tiredness, difficulty exercising, or collapse. Others may look well despite changes already developing in their organs.

Signs to watch for

Tiring unusually easily during activity
Episodes of low energy
Collapse during activity
A swollen abdomen

Liver changes can begin in puppyhood, while visible signs vary and may appear much later.

Emergency Go to an emergency vet now if your dog collapses.

Diagnosis and tests

A DNA test can identify the AGL gene variant reported in Curly-coated Retrievers, including dogs carrying one copy. Vets may also use blood tests to assess liver and muscle changes. Liver or muscle samples can show excess glycogen and reduced activity of the enzyme needed to break it down.

Breeds with documented risk

1 breed

By breed size

1 Large

Curly-coated RetrieverLarge · Sporting Group

Inheritance

Autosomal recessive
Curly Coated Retriever
A dog is affected only if it inherits two copies of the gene variant, one from each parent. A dog with one copy is a carrier: usually healthy, but able to pass the variant on. When two carriers are bred, on average one puppy in four is affected. A DNA test can tell clear, carrier and at-risk dogs apart.
As stated by OMIA

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.