Neuroaxonal Dystrophy in Dogs

Category: Nervous System & Behavioral
Breeds documented: 2
Published sources: 7

Overview

Damage to nerve fibers lies at the heart of neuroaxonal dystrophy. The fibers develop abnormal swellings, disrupting the nervous system and the dog's control of movement. Affected dogs may become unsteady, take exaggerated steps, or develop tremors. Several forms occur, with different genetic causes and ages at onset. How quickly signs worsen depends on the particular form.

Signs to watch for

Unsteady walking and poor balance
Exaggerated high steps or poorly judged foot placement
Trembling during movement
Repeated involuntary movements of the eyes
Changes in behavior, such as unusual nervousness

Onset varies by form, from puppyhood to young adulthood.

When to get help Arrange a veterinary examination soon for new unsteadiness or unusual movements.

Diagnosis and tests

A vet starts with the history and a neurological examination to assess balance, movement, and reflexes. DNA tests can help identify known inherited forms, including the changes linked to Spanish Water Dogs and Rottweilers. Microscopic examination of nervous tissue identifies the characteristic swollen nerve fibers.

Breeds with documented risk

2 breeds

By breed size

1 Medium
1 Large

RottweilerLarge · Working Group
Spanish Water DogMedium · Herding Group

Inheritance

Not yet known
None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.