Progressive Retinal Atrophy 3 in Dogs

Category: Eye
Breeds documented: 2
Published sources: 5

Overview

A change in the FAM161A gene is associated with PRA3, an inherited form of progressive retinal atrophy. It was identified in Tibetan Spaniels and Tibetan Terriers and affects the retina, the light-sensitive tissue lining the back of the eye. Retinal cells gradually lose function, reducing vision and potentially leading to complete blindness. Other genetic forms of retinal atrophy can occur in the same breeds, so not every case is caused by PRA3.

Signs to watch for

Reluctance to enter a dark room
Hesitating before going down stairs
Bumping into objects in new places
Pupils appearing unusually wide

Usually recognized in adulthood; Tibetan Spaniel reports describe diagnosis around five years of age.

When to get help Arrange a vet visit if your dog seems less confident moving around in low light.

Diagnosis and tests

Vets look for characteristic changes in the retina during an eye examination. A DNA test is available for this variant. The FAM161A variant does not explain every case of progressive retinal atrophy in Tibetan Spaniels or Tibetan Terriers, so genetic results need to be considered alongside eye findings.

Breeds with documented risk

2 breeds

By breed size

2 Small

Tibetan TerrierSmall · Non-Sporting Group
Tibetan SpanielSmall · Non-Sporting Group

Inheritance

Not yet known
None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.