Progressive Retinal Atrophy, crd4/cord1 in Dogs

Category
Eye
Breeds documented
9
Published sources
6

Overview

Changes in the RPGRIP1 gene are associated with this form of progressive retinal atrophy. It affects the retina, the light-sensing tissue at the back of the eye. Vision can decline as retinal cells deteriorate. The age at onset and severity vary, partly because other genetic changes influence the disease. A positive DNA result alone does not reliably predict vision loss.

Signs to watch for

  • Hesitating in dark rooms or outside after sunset.
  • Bumping into objects in unfamiliar places.
  • Pupils that look unusually large.

Onset varies widely; additional genetic changes can influence when retinal disease appears.

When to get help Book a vet visit when you notice changes in your dog's vision.

Diagnosis and tests

DNA testing can identify the RPGRIP1 variant linked to cord1. A veterinary eye specialist also examines the retina and may measure its response to light with an electroretinogram. Genetic results need interpretation alongside eye findings because the same variant can be associated with very different disease severity.

Breeds with documented risk

9 breeds

By breed size
  • 2 Toy
  • 3 Small
  • 3 Medium
  • 1 Large

Most popular breeds on this list

All 9 breeds, A to Z

Inheritance

  • Not yet known

    None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.

Sources

  1. ofa.org
  2. pubmed.ncbi.nlm.nih.gov
  3. vet.cornell.edu
  4. vet.tufts.edu
  5. merckvetmanual.com
  6. Beagle: pubmed.ncbi.nlm.nih.gov