Spongy Degeneration with Cerebellar Ataxia 1 in Dogs

Category: Nervous System & Behavioral
Breeds documented: 5
Published sources: 5

Overview

Damage to nerve tissue can cause severe loss of coordination early in puppyhood. The name SDCA1 describes sponge-like changes in nerve tissue and ataxia, meaning poor coordination. Puppies may stand with their feet spread apart, sway, stumble and fall. The disorder can progress rapidly, and some puppies lose the ability to walk while still very young.

Signs to watch for

Unsteady walking with the feet held far apart.
Body swaying, repeated stumbling or falls.
Trembling that becomes stronger during purposeful movement.
Hopping with the back legs together.

Signs commonly appear at about 4 to 8 weeks of age.

When to get help Arrange a prompt vet visit for a puppy that staggers, trembles or repeatedly falls.

Diagnosis and tests

Vets assess movement and balance, then can use a DNA test for the KCNJ10 variant associated with SDCA1. The test targets this particular inherited form rather than every cause of poor coordination. Other genetic disorders can produce similar signs, so results need to be interpreted alongside the clinical examination.

Breeds with documented risk

5 breeds

By breed size

2 Medium
3 Large

Belgian MalinoisLarge · Herding Group
Belgian TervurenLarge · Herding Group
Belgian SheepdogLarge · Herding Group
Belgian LaekenoisMedium · Herding Group
Bouvier Des ArdennesMedium · Foundation Stock Service

Inheritance

Not yet known
None of the sources we use states how this is inherited in dogs yet.

We've gathered what published sources say about this condition, so you can talk it through with your vet. It isn't veterinary advice: you and your vet know your dog best.